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However, cancer cells generally do not correct these errors, resulting in daughter cells with abnormal numbers of chromosomes, which may help these cancer cells develop resistance to chemotherapy treatments.
In their study, Dartmouth researchers Lilian Kabeche, Ph D, and Duane Compton, Ph D, show that microtubule attachments at kinetochores are very unstable in early phases of division.
"An analogy for this process could be dating," said Compton, Senior Associate Dean for Research and professor of biochemistry at Dartmouth's Geisel School of Medicine.
"The chromosomes are testing the microtubules for compatibility—that is, looking for the right match—to make sure there are correct attachments and no errors.
The goal of the MMI interview is to place applicants in scenarios that can demonstrate a candidate's social and communication skills, how they handle unknown situations, how they respond to ethical questions, and to give Med Schools a more holistic "view" of a candidate in action.Therefore, understanding how kinetochore-microtubule attachments are regulated throughout cell division is important, not only for furthering our understanding of cell division, but also for allowing us to correct these problems in cancer cells." For more information about this study, please visit